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MPs also interfere with bile acid conversion, lowering secondary bile acids such as lithocholic acid and deoxycholic acid, which normally suppress NFB and NLRP3 signaling via FXR/TGR5 and maintain Th17/Treg balance

PLoS One 7, e37512

In parallel, adenosine-5-phosphosulfate can be further phosphorylated to 3-phosphoadenosine-5-phosphosulfate, which is used for sulfation reactions (Mugford et al., 2011

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