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Mtb can also incorporate propionyl-CoA into its cell wall, including the virulence-associated lipids phthiocerol dimycocerosates (PDIM) and the trehalose ester family (sulfolipid-1 (SL-1), diacyltrehalose, triacyltrehalose, and polyacyltrehalose), which are synthesised from malonyl-CoA (produced from acetyl CoA) and methylmalonyl-CoA (produced from propionyl-CoA) (Lee et al, 2013)

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LMNA (A539V) and LMNA (W520G) were considered novel protein variants at the time of our studys inception, and based on the phenotypes observed in the F0 and F1 transgenic fish, we speculate that both variants may possess pathogenic roles