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Linagliptin but not sitagliptin inhibited transforming growth factor-beta2-induced endothelial DPP-4 activity and the endothelial-mesenchymal transition

Therefore, despite encouraging early evidence, the role of GLP-1 RAs in slowing or preventing DPN progression remains uncertain

As Yuval Ramot from the Department of Dermatology at Hadassah Medical Center notes: "Almost all local reactions to subcutaneously administered biological agents can be prevented by changing the injection techniques, patient education, and training." While most redness and warmth from injections resolve within 24 to 48 hours, mistakes in technique can prolong these symptoms