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Its defining structural feature is an N-terminal trans-3-hexenoic acid modification, a short unsaturated fatty acid attached to the amino terminus that shields the peptide from rapid enzymatic degradation by dipeptidyl peptidase IV (DPP-IV)

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The results showed that more patients in the combination group achieved the primary outcome and resolution of MASH than did those in the placebo group, while there was no significant difference between the vitamin and placebo groups, suggesting the beneficial effect of pioglitazone on MASH

These small but impactful changes can set you up for a smoother adjustment period while keeping your healthcare team in the loop