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Wadden, PhD, a professor of psychology in psychiatry at Perelman School of Medicine at the University of Pennsylvania, and colleagues noted

The complex structure shows that shikonin forms a hydrogen bond network with the catalytic dyad C145 and H164 located in the S1 subsite

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However, safety profiles at higher doses in this population require careful evaluation. Investigators encourage future studies to include a larger sample size to determine the efficacy of GLP-1 receptor agonists and other incretin therapies for the treatment of AUD