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Compared with mammals, fish have a lower ability to use carbohydrates as energy sources ( Reference Wilson 73 ) , but interactions between lipid and carbohydrate metabolism have been demonstrated in fish ( Reference Polakof, Mdale and Larroquet 74 , Reference Borges, Valente and Vron 75 )

In addition to mutations that activate the MAPK pathway, a key signaling pathway in melanocytic neoplasia altered in nevi, they harbor additional mutations that affect other biological processes and lead to phenotypic changes