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On further time-based analysis, we demonstrated a modest reduction in weight with GLP-1 RA use within the first 3 years (2.7% of baseline body weight) before rebounding to above baseline at 5 years

Many drugs today work by inhibiting proteins or suppressing gene expression, and these are straightforward to model genetically: individuals carrying homozygous loss-of-function variants serve as natural experiments that predict the maximal efficacy achievable by inhibiting that protein

A warm sensation during and immediately after injection is frequently reported

To become useful again, the body must use a specific enzyme called glutathione reductase to "recycle" it back into the reduced state