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Cardiologists involved in obesity research have raised particular concern about sympathomimetic-GLP-1 combinations in patients with hypertension, arrhythmia history, or coronary artery disease

It's a hard-and-fast rule that should never be bent if you're serious about your work

This interaction triggers intracellular signalling cascades such as the PI3K-AKT and MAPK pathways, which are critical for regulating cell growth, survival, and metabolism

Science 376 , eabl4290 (2022)