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Losing weight that includes a large proportion of muscle might result in a smaller number on the scale but may not lead to the desired firmer, more "toned" appearance

Journal of the Neurological Sciences, 304 (12)

However, Sovaldi was ultimately able to overcome this resistance by demonstrating strong clinical efficacy via multiple Phase 3 studies

PMID: 11354389 DOI: 10.1016/s0149-2918(01)80059-x Zapukhliak O et al (2021): Mecamylamine inhibits seizure-like activity in CA1-CA3 hippocampus through antagonism to nicotinic receptors