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Gregorj C, Petrucci MT, De Cave F, Scerpa MC, Vitale A, Ricciardi MR, Precupanu C, Cimino G, Mancini M, Vignetti M, Milella M, Andreeff M , Mandelli F, Foa R, Tafuri A

TLR4 activation may lead to ROS signaling via direct interaction between TLR4 and NADPH oxidase (Gill et al., 2010

developed a PH-responsive NO nanogenerator comprising isosorbide dinitrate (ISDN) -coated copper sulfide (CuS)/calcium carbonate (CaCO 3 ) core/shell nanoparticles (CuS@CaCO 3 -ISDN) to target the acidic microenvironment of infected diabetic wounds (Fig

Ice provides local pain relief without suppressing the inflammatory healing response