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Thus, suggesting that while individually, the DVC and the hypothalamus, appear to be sufficient to mediate the effects of GLP-1R agonists on energy balance, activation of multiple GLP-1R-responsive sites in the brain is necessary for endogenous GLP-1R regulation of feeding

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First-line pharmacotherapy consists of glucagon-like peptide-1 (GLP-1) receptor agonists such as liraglutide (Saxenda) and semaglutide (Wegovy) delay gastric emptying, reduce hunger, and increase satiety, resulting in weight loss