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Furthermore, the physiological or therapeutic significance of this enzymatic cleavage is unclear because DPP4 inhibitors universally decrease levels of intact glucagon in rodents and humans via potentiation of GLP-1 action, and circulating levels of glucagon [329] and glucagon [529] have not been reported in animals or humans treated with a DPP4 inhibitor

doi: 10.1016/j.indcrop.2023.116801 124 XuT.ChenL

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This has spurred considerable interest in devising novel therapeutic interventions that modulate its intricate regulatory pathways