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Exenatide dosage is not recommended to be increased in patients with an estimated glomerular filtration rate (eGFR) of 3060 mL/min/1.73 m 2

520,526 In the context of T2DM, liraglutide, by regulating the PI3K/Akt pathway and activating GLP-1R, effectively inhibits the growth and spread of pancreatic cancer cells

Nonetheless, the broader safety profile of GLP-1 drugs remains under close watch, particularly as more individuals begin using them for extended periods

Diabetes significantly increases the risk of developing depressive symptoms influenced by factors such as demanding self-management routines, fear of long-term complications, and the physiological stress imposed by persistent dysglycemia [31, 32]