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Each cage was equipped with water bottles and food hoppers connected to load cells (MM-1, Sable Systems International) for food and water intake monitoring

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The representative transcription factors mediated by HDACs include p53, signal transduction and activation of transcription 1 (STAT1), STAT3, GATA-binding factors (e.g

The direct regulation of GLP-1 on insulin expression is significant for type 2 diabetes (T2D) patients with simple glucose tolerance but normal insulin secretion ( 2 Peptide-based GLP-1 derivatives and small molecule compounds of GLP-1RA There are two main categories of GLP-1 receptor agonists, small molecule compounds and peptide-based GLP-1 derivatives as shown in Figure 1 , including exenatide, liraglutide, dulaglutide, etc