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This phase 1b/2a randomized, placebo-controlled trial enrolled 16 patients with type 2 diabetes and progressive DKD, who were allocated in a 3:1 ratio to receive either a single intravenous infusion of 80 106 ORBCEL-M cells (CD362-selected, allogeneic bone marrowderived MSCs) or placebo (253)

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203 The N-terminus contains the major nuclear hormone receptor-interacting motif (LXXLL), which facilitates ligand-dependent interactions with different transcription factors like ER, 204 PPAR, 205 RXR, 206 glucocorticoid receptor and HNF4

Fix: Store in refrigerator, protect from light, use within 4-6 weeks of reconstitution