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The SURMOUNT trials demonstrated average weight loss of 2022% at the 15 mg maintenance dose, with some participants achieving reductions exceeding 25%

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To summarize these mechanisms and their corresponding efficacy with GLP-1RAs or GLP-1, GLP-1RAs show the endothelial protective properties and thus owe to modulating vascular tone and maintaining endothelial barrier integrity, as well as the anti-adhesive and anti-thrombotic actions

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