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The surprising impact of organ donation opt-out policies Many countries around the world have adopted an opt-out approach to organ donation, where every eligible person is a donor after they die unless they opt out

These modest improvements occur indirectly through weight loss and improved glycaemic control rather than direct effects on lipid metabolism

Intriguingly, a recent randomised controlled trial found that metformin significantly improved depressive symptoms in patients with treatment-resistant bipolar depression [134]

Patients considering these therapies should understand the possible side effects, their own risk factors, and the warning signs that demand urgent attention