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The second class of inducers can directly inhibit GPX4 and cause ferroptosis

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Furthermore, membrane phospholipids bound to polyunsaturated fatty acids (PUFAs) are highly sensitive to free radical damage, leading to the accumulation of lipid peroxides (such as LOOH) [52]

I would say that the utilization of the BRI is less in consideration because it hasnt been taken into electronic medical records