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In contrast, short-acting formulations such as exenatide and the older-generation agent lixisenatide are now prescribed far less frequently, and several formulations have been withdrawn from the market in certain countries, largely due to limited clinical uptake, the availability of more effective long-acting alternatives, and commercial considerations rather than confirmed safety concerns

Glutamate decarboxylase 65 signals through the androgen receptor to promote castration resistance in prostate cancer

Mutation of this enzyme leads to fumarate accumulation not only in skin cancer and uterine leiomyomas but also in breast, bladder, and Leydig cell tumors 130

The FDA investigation is not the first time an association between suicidal ideation and GLP-1 medications has been reviewed