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However, caution should be exercised because although the administration of VEGF has a beneficial effect by reducing the formation of edema, the infusion of VEGF may also cause vascular leakage, which may consequently result in hemorrhagic transformation of ischemic lesions (Korn 2008)

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116 Astrocytic asthenia is also manifested by the limited reactivity in the most vulnerable brain regions such as entorhinal and prefrontal cortices in which astrocytes do not mount a defence response in the presence of -amyloid depositions

The study found that peripheral endothelial dysfunction independently correlated with future cardiovascular events, thus providing additional clinical significance for risk stratification in HFpEF patients