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This results in a significant transfer of electron density from the HOMO to the LUMO, ultimately transferring nearly 1 e from the gravitation monoanion to the structures of vitamin B12 forms like cyanocobalamin, aquacobalamin
However, its clinical application must be approached with a critical and nuanced understanding of the current evidence gap
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However, following ingestion of a large overdose (150 mg/kg or greater) the glucuronide and sulfate conjugation pathways are saturated resulting in a larger fraction of the drug being metabolized via the P-450 pathway
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