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This inextricably links gliotoxin/BmGT formation to the cellular Methyl/Met cycle via GtmA (Owens et al., 2015) (Figure 2) and leads to the conclusion that biosynthesis and dissipation of the disulfide-containing non-ribosomal peptide gliotoxin requires significant utilization of cellular sulfur-containing metabolites, GSH and SAM (Figure 2)

local SARP, PRO12070359) and all subjects provided written informed consent prior to participation in the study and were identified by different numbers, not by names