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Muscle preservation during caloric deficit requires a mechanical stimulus that tells the body "these muscles are being used, do not break them down for energy." Without that signal, up to 40% of weight lost can come from lean tissue rather than fat

Alongside it, companies are developing next-generation dual-agonists like Novo Nordisks CagriSema (combining semaglutide with an amylin analogue) and Boehringer Ingelheims Survodutide

Stopping abruptly often leads to weight regain, so coming off is done gradually and under supervision

Your hypothalamus, a part of your brain, and your pituitary gland, a small gland right below the hypothalamus, typically tell your thyroid how much of each hormone to produce