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Most prior incretin-family peptides act on one or two of these receptors: Semaglutide (single agonist): GLP-1 receptor only Tirzepatide (dual agonist): GLP-1 + GIP receptors Retatrutide / GLP-3RT (triple agonist): GLP-1 + GIP + glucagon receptors That third receptor glucagon is the key reason researchers describe GLP-3RT as a next-generation tool in incretin pharmacology research
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Moreover, stimulation of LS GLP-1R neurons reduced food intake, both in an acute and chronic manner, while inhibition increased food intake [108,109]
These symptoms typically occur at the beginning of therapy and gradually subside as your body adjusts to the active ingredient
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