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This includes measuring BMI and waist circumference, screening for obesity-related comorbidities (such as hypertension, dyslipidaemia, and impaired glucose tolerance), and evaluating psychological wellbeing

Glucagon agonism raises theoretical concerns about hyperglycemia in insulin-resistant populations, though fasting glucose remained stable or improved across all retatrutide arms

If the picture is unclear, MRI can reveal cartilage damage, tendon problems, labral tears, masses, or other issues that cannot be felt from the outside

As of 2025, the entire human evidence base for a compound injected by millions amounts to a retrospective study of 16 knee patients, a 12-patient bladder pain pilot with no control group, and a two-person intravenous pharmacokinetic study