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By reducing peripheral inflammatory signals, improving vascular health, and restoring metabolic homeostasis, semaglutide may alleviate the major drivers of neurodegeneration, suggesting that its neuroprotective benefits may not depend solely on high concentrations within the brain parenchyma

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The purified non-acylated tirzepatideGIPRmini-G s Nb35 complex at a concentration of 14-16 mg/mL was mixed with 100 M non-acylated tirzepatide at 4C and applied to glow-discharged holey carbon grids (Quantifoil R1.2/1.3, Au 300 mesh) that were subsequently vitrified by plunging into liquid ethane using a Vitrobot Mark IV (ThermoFisher Scientific)

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