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This is a methodological limitation that has been misrepresented in both the scientific literature and in popular media

If headaches significantly impair quality of life or prevent continuation of treatment, the prescriber may consider dose adjustment, switching to an alternative medication, or discontinuation if necessary

The good news: most side effects are manageable and often ease with dose pacing, smart food choices, hydration, and knowing when to call your clinician

Blood markers confirm this: patients in rapid weight loss phases show decreased glutathione-to-GSSG ratios (the oxidised form), indicating depletion