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however, the differences between the vitamin and placebo groups were not statistically different at any of the measured timepoints (3 months, 6 or 9 months, and 12 months) (103)

The restoration of the early insulin peak secondary to glucose and the stronger reversible binding of gliclazide MR to the cells SUR1 receptor compared to other SUs could be responsible for reduced pancreatic stimulation, which translates into a reduced incidence of hypoglycemia [22]

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