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Eleftheriadis N, Neochoritis CG, Leus NG, van der Wouden PE, Domling A, Dekker FJ

Ca 2+ also activates the cysteine protease calpain-1, which degrades cytoskeletal proteins such as the ankyrin-R complex, promoting membrane blebbing and increasing cellular adhesiveness (Restivo et al., 2021)

Replenishes essential energy to skin cells, maintains normal skin cell metabolism, while inhibiting melanin, brightening, soothing, promoting blood circulation, and combating free radicals to prevent wrinkles and prevent skin tissue sagging and loss of elasticity

[67] developed a nanoplatform that utilizes high concentrations of ROS and intestinal enzymes in the colon to pinpoint sites of inflammation, which has been shown to be effective in reducing systemic drug exposure and adverse effects