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Diarrhea, which occurs in approximately 15-23% of patients taking tirzepatide (with higher rates at higher doses and in the weight management indication), can independently cause visible mucus in stool

Which controls & decreases melanin production and reduces pigmentation

Chronic oxidative stress can lead to a depletion of cellular glutathione levels

Another reading suggests that broad gene-expression effects can reflect secondary consequences (changes in cell state, in proliferation rate, in metabolism) rather than direct mechanism-based effects, and that the specificity of the transcriptomic findings should be interpreted with caution