Functional effects in the pancreas include the glucose-dependent release of insulin, as well as an up-regulation of the biosynthesis of insulin, glucokinase, and glucose transporters
However, for probiotic therapies to be truly integrated into clinical practice, three practical challenges must still be addressed: verification of long-term safety, optimization of cost-effectiveness, and assurance of patient compliance
c tc dng lm sng da, h tr chng oxy ha, bo v da khi cc tc hi t gc t do
While some patients who did not meet these criteria were allowed to enroll for individualized valid clinical reasons (e.g., lower BMI with specific health concerns related to excess adiposity), this analysis focuses only on patients who met the formal program eligibility