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Neutrophil extracellular traps promote macrophage inflammation and impair atherosclerosis resolution in diabetic mice
Recommendations include: 150-300 minutes weekly moderate-intensity aerobic activity Resistance training 2-3 times weekly to maintain muscle mass Non-exercise activity thermogenesis (NEAT) optimization through increased daily movement Pharmacological Alternatives: Beyond GLP-1 receptor agonists, FDA-approved weight loss medications include: Phentermine-topiramate (Qsymia): Appetite suppressant combination Naltrexone-bupropion (Contrave): Affects reward pathways and appetite Orlistat (Xenical, Alli): Lipase inhibitor reducing fat absorption These alternatives have different mechanisms, adverse effect profiles, and efficacy (typically 5-10% weight loss), allowing individualized selection
Set a schedule: Take your dose at the same time each day to build a habit
Ranganath and colleagues also tracked changes in RA medications as a surrogate for disease activity
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