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cacao formed a phylogenetic group with subcellular localization in the endoplasmic reticulum ( Figure 8 4 Discussion 4.1 Plant GPXs protect cells against cell death, just like animal GPX4s/PHGPX Pathogen infection induces oxidative stress in plants, leading to ROS accumulation that disrupts membrane integrity through lipid peroxidation (Torres et al., 2006), destabilizing cellular homeostasis and amplifying stress responses (Sharma et al., 2012