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A metabolomic analysis targeting tryptophan metabolism showed that inulin intervention upregulated fecal levels of indole-3-acetate and kynurenine in rats with NAFLD, while downregulating levels of kynurenine and 5-hydroxyindoleacetic acid ( Role of inulin in disease Inulin can regulate the metabolism of glucose, lipids, and amino acids in addition to intestinal immune and systemic immunomodulatory effects

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Int J Mol Med 41(2):818828 Yang Q, Jia B, Shang J, Wang X, Xu L, Liu X, Gong Z (2024) Effects of rosmarinic acid on immune response and intestinal microbiota in ovalbumin-induced intestinal allergy mice

273 In addition, in a rat model of inflammatory OA induced by monoiodoacetic acid (MIA), researchers have shown that the activation of GLP-1R triggers the PKA/CREB signaling pathway, leading to a reduction in cartilage inflammation