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5.6 Hypoglycemia with Concomitant Use with Insulin or Insulin Secretagogues JANUMET may increase the risk of hypoglycemia when combined with insulin and/or an insulin secretagogue (e.g., sulfonylurea) [see Adverse Reactions (6)]

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1 Arthroscopic procedures reveal the presence of chondral lesions in greater than 60% of patients, 2,3 and yearly incidence rates of chondral lesions nearly tripled between 1996 and 2011