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Abbreviations BMI: Body mass index BP: Blood pressure CEAC: Cost-effectiveness acceptability curve CHEERS: Consolidated Health Economic Evaluation Reporting Standards COM: Core Obesity Model DGS: Direo Geral da Sade D&E: Diet and exercise EMA: European Medicines Agency GLP-1: glucagon-like peptide-1 HDL: High density lipoprotein ICER: Incremental cost-effectiveness ratio LY: Life years MI: Myocardial infarction NHS: National Health Service SPEO: Sociedade Portuguesa para o Estudo da Obesidade STEP: Semaglutide Treatment Effect in People with obesity program SBP: Systolic blood pressure TIA: Transient ischemic attack T2D: Type 2 diabetes WTP: Willingness to pay References Seidell JC, Halberstadt J

Evidence on GLP-1RA-associated retinopathy progression is mixed: the SUSTAIN-6 trial noted early worsening among patients with pre-existing proliferative disease, likely related to rapid glycemic improvement, while multiple meta-analyses and real-world studies have not shown increased long-term retinopathy risk

Animal models and experiments

If you discover through an elimination diet that you have a sensitivity to histamine, sulfur, salicylate, or oxalate, I recommend temporarily reducing foods high in those compounds