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This interference with glycolysis disrupts Th17 cell differentiation, thereby alleviating rheumatoid arthritis ( + T cells from the peripheral blood of patients with rheumatoid arthritis, catalpol upregulates miR-143-3p, inhibits the abnormal differentiation of Th17 cells, and downregulates glycolysis, thereby regulating the immune balance and exerting anti-inflammatory effects (Shen et al., 2022

Mechanisms of ovarian aging

In imiquimod-induced lupus mice, the prebiotic Hirsutella sinensis polysaccharides and the probiotic Parabacteroides goldsteinii significantly reduced disease markers, including spleen weight, proteinuria, anti-dsDNA autoantibodies, and STAT signaling levels, while improving renal and hepatic function parameters