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Additionally, gut commensals such as Butyricicoccus pullicaecorum , Butyrivibrio fibrisolvens , Ruminococcus bromii , and members of the family Lachnospiraceae also produce sodium butyrate upon fermenting dietary fibers, which inhibits CRC cell proliferation by regulating immune cells such as natural killer cells and macrophages, and causes apoptosis (Xi et al., 2021)

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