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( 10.2337/db09-1694) [DOI] [PMC free article] [PubMed] [Google Scholar] 33.Rakipovski G, Rolin B, Nhr J, Klewe I, Frederiksen KS, Augustin R, Hecksher-Srensen J, Ingvorsen C, Polex-Wolf J, Knudsen LB

Supports Inflammatory Balance Berberine has antioxidant and anti-inflammatory properties, which may help support general metabolic health

19,84 Hepatocyte-specific SIRT1 knockout mice display liver steatosis, triglyceride accumulation, and increased de novo lipogenesis, even under standard dietary conditions, accompanied by SREBP-1c activation and impaired PGC-1/peroxisome proliferator-activated receptor alpha (PPAR) signaling

Meticulous clinical oversight is vital for safety and long-term efficacy