Timing and frequency Standard semaglutide protocols call for once-weekly subcutaneous injection
Each needle puncture through the rubber stopper introduces small contamination risk, making proper sterile technique essential for each draw
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Extra caution is appropriate in patients with active cancer, recent cancer, unexplained masses, unexplained weight loss, pregnancy, breastfeeding, known allergy to peptide products, active infection, immune compromise, significant liver or kidney disease, active inflammatory or autoimmune disease flares, unusual clotting history, uncontrolled cardiovascular disease, use of chemotherapy or immune-modifying biologic therapy, and competitive athletes subject to anti-doping rules