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To monitor ATP release in real time, we used sniffer patches 16 , composed of slowly-inactivating P2X 2 receptors 17 over-expressed in HEK293 cells, as a local ATP sensor

Factors such as obesity, diabetes status, and genetic background can also affect the plasma level and receptor sensitivity of PYY, resulting in significant differences in the efficacy of different patients

These include glucagon-like peptide receptor agonists (GLP1-RAs) and dipeptidyl peptidase 4 inhibitors (DPP4is), whose mechanisms of action, albeit different, are mainly related to the action of the glucagon-like peptide 1 (GLP-1)

Ast J, et al