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Interaction with MC4R pathways linked to appetite regulation, energy balance, and neuroendocrine signaling

Seizure Threshold Considerations: Bupropion lowers the seizure threshold in a dose-dependent manner, which is why it is contraindicated in patients with seizure disorders

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EMT is a multi-step process in which epithelial cells lose their characteristic traits and gain mesenchymal features, including the loss of cell junctions and apicobasal polarity [33]