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Modifiable lifestyle and environmental factors associated with onset of psoriatic arthritis in patients with psoriasis: a systematic review and meta-analysis of observational studies

Meta-analyses of randomized trials corroborate these findings: one large review of 27 RCTs reported no significant difference in suicidality between GLP-1 RAs and placebo (RR 0.76) [48], while another meta-analysis including 25 trials similarly showed no association across multiple subgroups and endpoints (RR 0.84) [49]

This implies that no manual mixing by the physician is required