l carnitine mitochondrial disease The Role of L-Carnitine in Kidney and Related Metabolic Dysfunctions Carnitine Deficiency: What You Need

Effect of Methylfolate, Pyridoxal-5'-Phosphate, and Methylcobalamin (Soloways(TM)) Supplementation on Homocysteine and Low-Density Lipoprotein Cholesterol Levels in Patients with Methylenetetrahydrofolate Reductase, Methionine Synthase, and Methionine Synthase Reductase Polymorphisms: A Randomized Controlled Trial

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This appears to be dose-dependent, with moderate doses enhancing sleep quality while excessive doses may paradoxically impair deep sleep architecture

The right trial would be in people w ithout any cognitive impairmen t but at high-risk as defined by family history, high polygenic risk score, APOE4 carrier or homozygotes, high levels of p-Tau217 and other blood biomarkers