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After 40, melatonin production declines measurably , pineal calcification accelerates, and sleep architecture progressively deteriorates

Blood 108 , 32713279 (2006)

Non-genotoxic p53 activation and blockade of Bcl-2 signaling synergistically induce apoptosis in AML through induction of Noxa and Bak/Bax heterodimerization