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Discovered in the early 1970s, DSIP has been extensively studied for its potential to enhance sleep quality, reduce stress, and improve overall well-being

Taking into account our estimated changes in enrollment, utilization, and case-mix for CY 2026 we estimate that the OPPS expenditures, including beneficiary cost-sharing, for CY 2026 will be approximately $101.0 billion, which is approximately $8.0 billion higher than estimated OPPS expenditures in CY 2025

Active ingredients come from FDA-registered suppliers with certificates of analysis

Food and Drug Administration (2015) Lithium, National Alliance on Mental Illness (2023) Common pain relievers carry risks, Arthritis Foundation (2021) Nonsteroidal anti-inflammatory drugs and the kidney, Pharmaceuticals (2010) Alcohol and NSAIDs increase risk for upper GI bleeding, American Family Physician (2000) Review of herbal medications with the potential to cause bleeding: Dental implications, and risk prediction and prevention avenues, EPMA Journal (2019) Ibuprofen drug label information, DailyMed (2022) Ibuprofen, LiverTox (2018) FDA recommends avoiding use of NSAIDs in pregnancy at 20 weeks or later because they can result in low amniotic fluid, U.S