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Its concentration in human plasma is reported to decline substantially from young adulthood into later middle age, a decline that Pickarts later reviews use as the conceptual rationale for reintroducing the peptide
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Better circulation brings more oxygen and nutrients directly to the hair follicle, which is essential for the growth phase
This decline correlates directly with the loss of regenerative capacity that comes with aging, which is part of why older individuals struggle more with skin elasticity after weight loss
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