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Exposure to light, on the other hand, decreases melatonin production and signals your body that its time to wake up and be alert

10.1002/ana.10483

This has been demonstrated by Gough et al

Above all, oral delivery systems using bile acids to target the apical sodium-dependent bile acid transporter (ASBT) have achieved significant improvements in the intestinal permeability of not only hydrophilic small-molecule anticancer drugs, but also macromolecules [42, 43]