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If you're augmenting growth hormone in your teens, your 20s, you can really mess up your hypothalamic-pituitary-body axis, all the organs of your body in major ways." Andrew Huberman He also raised the fundamental trade-off between vitality and longevity noting that substances which enhance muscle growth, recovery, and fat loss may also accelerate aging through elevated growth hormone and IGF-1 signalling

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Since medical weight loss may reduce lean muscle mass by up to 30%, its crucial to mitigate this