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They also urge caution for people with diabetes who are using GLP-1 drugs off-label or for weight loss, especially when experiencing side effects that might lead them to consider dialing back their insulin dosage

If you experience severe vomiting or diarrhea that prevents you from keeping fluids down, seek medical attention promptly

Licensed options in the UK include orlistat (oral), semaglutide 2.4 mg (Wegovy, approved by NICE TA875 for eligible patients), and tirzepatide (Mounjaro for type 2 diabetes

Survodutide, a glucagon/GLP-1 dual agonist, met its primary endpoint of histological improvement in MASH at 48 weeks and also demonstrated a statistically significant improvement in fibrosis, a secondary endpoint